Lewis lost the lead off the start to rival Sebastian Vettel, but moved back past the Ferrari early on to take his ninth win of the 2017 Formula 1 season and his fifth at the Circuit of The Americas.
"Firstly, I want to say big congratulations to everyone in the team - both back at the factory and here," said Lewis. "There has been an incredible push for this kind of performance this year.
"We really pulled together more than I have experienced and seen over the last five years to create something quite special.
"I'm really proud for everyone, especially going from one era of car to another which is something that has never been done before. It shows the strength of the team and I'm proud to be part of it.
"The race was great, it was probably one of the most fun races that I have had for a while - and there were quite a few fun ones this year. I didn't get away to a great start, but I was kind of chilled about it, knowing from the past that I can overtake here.
"I had a lot of fun trying to get closer and overtaking. Today the wind changed 180 degrees and it made the track so special to drive; the car felt amazing going through the Esses. We have three more races left this season - and that's three I want to win."